maladie de dupuytren origine viking

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Compared with 500 random samples of 21 SNPs taken from across the genome, the DD-associated SNPs do not show an increase in within-population structure (p = 0.072, Figure 2(a)), which would have been expected had DD been associated with Norse ancestry. In conclusion, our genetic analyses directly contradict the widely held belief, especially popular among patients, that DD is a disease of Norse origin. Causes et facteurs de risque de la maladie de Dupuytren. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: DF was supported by an Intermediate Clinical Fellowship from the Wellcome Trust [097152/Z/11/Z]. However, there are nine or ten different genes associated with Dupuytren’s and this suggests that it may have evolved on several different occasions. Age distribution of Dupuytren's contracture, influence of gender. Viking legacy makes a great story. Toutefois, aucun lien de cause à effet n'a été démontré entre ces deux maladies. Origines et signes de la maladie. The mean FST for cases and controls in the British Society for Surgery of the Hand – Genetic Origin of Dupuytren’s Disease dataset. (b) Lactase-associated SNP rs4988235 shows a highly significant decrease in local haplotype sharing. http://www.creativecommons.org/licenses/by/4.0/, https://us.sagepub.com/en-us/nam/open-access-at-sage, https://www.hsph.harvard.edu/alkes-price/software/, Common variants of the ALDH2 and DHDH genes and the risk of Dupuytren’s disease, Radiotherapy in Dupuytren’s disease: a systematic review of the evidence, Egawa T, Senuri S, Horiki A, Egawa M. Epidemiology of the Oriental patient. In addition, we thank the surgeons and researchers in the BSSH-GODD study who helped with recruitment of affected individuals. Elles s ét endent sur toute la largeur de la paume, en éventail. The aggregated GRS across the PoBI dataset does not show any geographical clustering in areas of known high Norse ancestry (Figure 2(c)), which would have been expected if the genetic predisposition to DD was derived from Norse ancestry. L'héritage viking (3) : Les Vikings n’ont pas laissé que des vestiges archéologiques. Dupuytren's disease: a legacy of the north? Linear regression analysis of hospital episode statistics predicts a large increase in demand for elective hand surgery in England, Effects of vibration on the hand-arm system of miners in India, The early history of contracture of the palmar fascia. Happy Holidays from the Dupuytren Research Group! Within the UK there are geographical population clusters that can be separated on the basis of their inherited genetic variation (Leslie et al., 2015). In: Mcfarlane RM MD, Flint MH (Eds). Madrid; Santander; Spécialités . We then aggregated these scores across the 35 population labels to investigate possible geographical structure associated with known regions of high Norse ancestry, such as the Highlands of Scotland. La maladie de Dupuytren est une maladie d'origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. (a) Dupuytren’s genetic risk score is not significantly different from random in a haplotype-based test for population structure. J'ai du mal à étirer mes doigts. It has been suggested that Dupuytren’s disease has an origin in Norse countries. Copyright © 2002 by the … Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. We found no evidence for an excess of Norse ancestry informative markers in our cases and the total FST of disease-associated SNPs was not in the top 5% of 10,000 randomly permuted SNP groups of the same size. English new terms dictionary; Interpretations; Translations; Books; English new terms dictionary  Dupuytren's contracture. Dupuytren’s disease (DD) is an ancient affliction of unknown origin. People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population, The British Society for Surgery of the Hand. The first author to suggest an origin and spread of Dupuytren's disease was Early who wrote in 1962, "If one postulates the condition as having arisen in one particular racial group (the Nordic for example) then the variable distribution in other parts of the world might be explained on the basis of migration from that group." En règle générale, la quantité d’alcool consommée (volume, fréquence et durée) détermine le risque et la gravité des lésions hépatiques. We harnessed data from a genome-wide association study of Dupuytren’s disease and the People of the British Isles study to determine evidence for a Norse origin of Dupuytren’s disease. Figure 2. Because we were interested in those SNPs that differentiated Orkney from the other populations, all negative FST values were set to zero (Garagnani et al., 2009). D’autres pathologies d’altération de gènes responsables de dégradation du collagène ont été également retrouvées. Dupuytren’s disease (DD) is a disease of the palmar fascia that causes flexion contractures of the fingers (Townley et al., 2006). DJL is supported by the Wellcome Trust and Royal Society [WT104125MA]. Il s’agit d’une fibrose rétractile de l’aponévrose palmaire moyenne de la main qui est une membrane située entre les tendons fléchisseurs de la main et la peau. Does Dupuytren by itself affect the risk of having other conditions? La Société canadienne de Dupuytren est présentement à la recherche d’un membre pour se joindre à notre comité de levée de fonds La société canadienne Dupuytren a été constituée et a reçu le statut d'organisme de bienfaisance en 2015. For each comparator group, the total FST of the DD-associated SNPs was not within the top 5% of ranked total FST of 10,000 permuted SNP groups (nominally p > 0.05, Figure 1(b,c,d). Optimising recruitment to the HAND-1 RCT feasibility study: integration of the QuinteT Recruitment Intervention (QRI). La Scandinavie et toutes les populations ayant été en contact avec les Vikings, lors des migrations, témoignent encore aujourd'hui du patrimoine génétique qu'ils ont légué au travers de pathologies héréditaires... car la maladie de Dupuytren n'est pas la seule maladie transmise par les vikings. For each analysis, FST was calculated between three comparator groups: Orkney vs Wales, Orkney vs South East, and Orkney vs combined Wales and South East. View or download all the content the society has access to. Briefly, the BSSH-GODD study included a total of 7912 cases of DD and 12,937 population-based controls. Some scepticism as to the Norse origin of the disease has been expressed by Elliot (1988). Dupuytren’s disease (DD) is an ancient affliction of unknown origin. These associations have revealed several novel pathophysiological insights and the risk alleles correlate with recurrence of DD after surgery (Riesmeijer et al., 2019). La maladie de Dupuytren est une maladie génétique. Hygiène au cabinet médical. Traitement de la maladie de Dupuytren: 'Dr, quelle est cette dureté sur la paume? Elle entraîne une rétraction et une flexion progressive et irréductible des doigts. La maladie de Dupuytren est une maladie qui touche généralement les personnes âgées, mais elle peut apparaître dès l’âge de 40 ans environ. Tradition has it that the disease originated with the Vikings, who spread it throughout Northern Europe and beyond as they traveled and intermarried. ,{i:'table2-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table2.gif',l:'10.1177_1753193419882851-table2.jpeg',size:'102 KB'}]} Furthermore, the lack of description of a disease resembling DD in Ancient Greek, Roman, Early Anglo-Saxon or Medieval European writings is further putative evidence of a Nordic origin of the disease (Elliot, 1988). From a literature search, it is proposed that Dupuytren's disease existed in Europe earlier than the Viking Age and originated much earlier in prehistory. In addition, with the exception of a high prevalence rate in Northern European communities, no actual genetic factors have implicated DD as … Resume La maladie de Dupuytren est caracterisee par une proliferation de tissu fibreux retractile dans la paume et a la face palmaire des doigts. La maladie de Dupuytren est une maladie d’origine inconnue qui touche des tissus (les aponévroses) dont le rôle est de protéger les muscles, les nerfs et les vaisseaux. Simply select your manager software from the list below and click on download. (b,c,d) Comparison of total FST for DD-associated single nucleotide polymorphisms (SNPs; blue line) compared with randomly permuted sets of SNPs. Maladie de Dupuytren : définition C'est une fibrose rétractile irréductible de l'aponévrose palmaire de la main avec rétraction et flexion des doigts, perception de nodules durs et épaississement de l'aponévrose palmaire moyenne. It sounds believable. (c) Dupuytren’s genetic risk scores are not associated with geography. ,{i:'fig2-1753193419882851',type:'fig',g:[{m:'10.1177_1753193419882851-fig2.gif',l:'10.1177_1753193419882851-fig2.jpeg',size:'1 MB'}]} Bien que cela ne soit pas totalement certain, cette maladie c’est diffusée surtout en Europe lors des invasions Viking, elle peut prendre des formes variables touchant les mains, les pieds (maladie de Ledderhose) et la verge (maladie de Lapeyronie). RAPPEL La maladie décrite en 1831 par le Baron Guillaume Dupuytren, chirurgien de l’Hôtel-Dieu de Paris, est génétique et d’origine Viking. Ethical approval for this study was obtained from: British Society for Surgery of the Hand Genetics of Dupuytren’s Disease (BSSH-GODD) study – Oxfordshire Research Ethics Committee B/09/H0605/65; People of the British Isles study – NRES Committee, Yorkshire and the Humber – Leeds West, UK 05/Q1205/35. Au fur et à mesure que la maladie évolue, ces tissus se rétractent entraînant la … Whaley and Elliot (1993) provided an account of four ‘miracles’ from Nordic sources, where a condition resembling DD was alleviated by miracle cures. First, epidemiological studies have shown that DD is more common in European populations and the prevalence seems to be highest in Iceland and Scandinavian countries that were the origin of the Viking Warriors (Hindocha et al., 2009). NORTHERN or Scottish people are more likely to develop ‘viking’ - or Dupuytren's - disease, which affects one million in the UK. Les fibres longitudinales prennent leur origine au nive au du tendon long palmaire ou, si ce tendon est absent, au niveau des fibres de l aponévrose antébrac hiale. Data used in this study are available from the European Genome-Phenome Archive (https://ega-archive.org), study numbers EGAS00001000672 and EGAS00001001206, The distribution of genomic FST in both cases and controls closely followed a normal distribution (Figure 1(a)). Lactase is under positive selection and therefore is expected to show much less population-specific haplotype sharing, and is therefore a positive control in this analysis. Find out about Lean Library here, If you have access to journal via a society or associations, read the instructions below. enacademic.com EN. La contracture de Dupuytren est un état graduel qui influence les doigts et les mains, entraînant au moins un doigt, et probablement plusieurs, à courber vers la paume de la main. For more information view the SAGE Journals Article Sharing page. For five credible sets, there was no representative SNP in the PoBI dataset (lead SNPs: rs117402009, rs2472141, rs1042704, rs61982174, rs34088184), meaning there were 21 DD-associated SNPs remaining for analysis. Copyright © 2002 by the … There has been a much quoted concept of DD being labeled as the “Viking“ or “Nordic“ disease. La maladie de Dupuytren est une sorte de pathologie qui se caractérise par la rétraction progressive d’un ou plusieurs ou doigts de la main. We then permuted 10,000 random sets of 21 SNPs within the PoBI dataset and calculated the total FST of each of these sets in each of the three comparator groups. ]}. window.figureViewer={doi:'10.1177/1753193419882851',path:'/na101/home/literatum/publisher/sage/journals/content/jhsc/2020/jhsc_45_3/1753193419882851/20200212',figures:[{i:'table1-1753193419882851',type:'table-wrap',g:[{m:'10.1177_1753193419882851-table1.gif',l:'10.1177_1753193419882851-table1.jpeg',size:'616 KB'}]} Maladie de Dupuytren, une orthèse pour maintenir le doigt en extension Une orthèse pour maintenir un doigt en extension après une opération de Dupuytren ©J.Redoux. Create a link to share a read only version of this article with your colleagues and friends. Le traitement classique était chirurgical, … LA MALADIE DE DUPUYTREN. les bons gestes. It is defined by Dorland as shortening, thickening, and fibrosis of the palmar fascia producing a flexion deformity of a finger. Elle se caractérise par une rétraction fibreuse de l’aponévrose palmaire moyenne entraînant une rétraction progressive et irréductible des doigts. Dupuytren’s disease (DD) is an ancient affliction of unknown origin. The higher the index for a particular single nucleotide polymorphism (SNP), the more different the allele frequencies of the SNP are between populations. Finally, a GRS derived from DD-associated SNPs did not show increased geographical clustering around areas of known high Norse ancestry. James Barrie, author of “Peter Pan” had a right contracture thought to be Dupuytren’s, which formed the source material for Captain Hook’s hook. The evidence for this assertion comes from two main themes. The GRS for DD from the 21 independent Dupuytren’s GWAS hits was calculated for each individual in the PoBI dataset. Elle entraîne une rétraction et une flexion progressive et irréductible des doigts. Dupuytren’s disease (DD) is a common progressive fibrotic condition affecting the palmar and digital fascia. Access to society journal content varies across our titles. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d’abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. The authors wish to acknowledge all of the individuals who participated in both studies. Dupuytren's disease is currently called a Viking disease on the assumption that the disease was spread to Europe and the British Isles during the Viking Age of the 9th to the 13th centuries. Résultats L’échantillon concerne 3025 agents. Furthermore, Elliot (1988) also comments on the lack of records of DD in the medical writings of the missionaries of Iona, the Roman Church in North Germany and North-East England, or the extensive medical writings from mediaeval Europe. Selon ce spécialiste de l’appareillage de la main et du membre supérieur, “le doigt à la. Townley, WA, Baker, R, Sheppard, N, Grobbelaar, AO. Pour des raisons mal connues, ces tissus deviennent épais, se pelotonnent d'abord en boule (les nodules) ce qui entraîne des plis dans la paume ou les doigts. Les choix therapeutiques restent donc incertains comme en temoigne la multiplicite des techniques chirurgicales et des …

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